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Lethal deformation of cancer cells in the microcirculation: A potential rate regulator of hematogenous metastasis

Crucial NITs in NAFLD patients stratification are especially the fibrosis-4 (FIB-4) - an index that takes into account age, transaminases and platelet count- and the liver stiffness evaluation by VCTE

As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)

In this process, accumulated iron promotes the phosphorylation of tau protein in the brains of CTE patients through oxidative stress and aggregates to form nerve fiber tangles (Shen, 2015)