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In endothelial cell models, BPC-157 significantly enhanced ERK1/2 phosphorylation in a dose-dependent manner, leading to increased cellular proliferation, migration, and vascular tube formation mediated through downstream activation of transcription factors c-Fos, c-Jun, and EGR-1

At the time of writing, GHK-Cu is available to researchers as a reference material for in vitro experimentation only

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For BPC-157, the FDA explicitly classified the compound as an "unapproved drug," and US regulatory authorities issued warnings on so-called "wellness" products containing it