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25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM

7:1034-1043 (2022) Acknowledgements This study was financially supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) (RS-2025-02218354) and by the R&D Program of MOTIE/KEIT (RS-2025-02307907)

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After several steps in the cycle, OAA is regenerated and ready to combine with another molecule of acetyl-CoA, allowing the cycle to continue