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17 The clinical efficacy of these drugs has been clearly shown in many studies and the superiority of PPIs over H 2 RAs has been established beyond doubt

The SEMALEAN trial found lean mass declined then stabilised while handgrip strength improved by 4.5 kg and sarcopenic obesity prevalence fell from 49% to 33% over twelve months

Butch, A.W., Ahrens, B.D

passive movement of drug from filtrate back to blood) A question arises: How can we easily predict the relative contributions of these 3 processes? Simple solution: Compare renal clearance (CLR) and filtration clearance (CLf)