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Al unirse a receptores especficos en el hipotlamo y el tronco enceflico, el GLP-1 estimula neuronas anorexignicas (POMC) y suprime neuronas orexignicas (NPY/AgRP), lo que se lleva a una mayor sensacin de saciedad y menor ingesta calrica

According to the Cleveland Clinic, GLP-1 medications help lower blood sugar, reduce appetite, and improve metabolic function

One of the key roles of Breakthrough T1D is funding the research and hoping that our funding will remove that initial barrier of entry. Several trials on the horizon are testing new treatments for type 1 diabetes

Ongoing research is probing novel applications of GLP-1 agonists beyond diabetes and obesity from potential use in metabolic dysfunction-associated steatohepatitis (MASH) to trials investigating neuroprotective effects in conditions like Parkinsons and Alzheimers disease, though the 2025 phase 3 trials in both conditions failed to show clinical benefit ( [24] ) ( [25] )