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When given by intramuscular injection, the dose bypasses the digestive tract and is absorbed reliably, which matters because dietary B12 absorption depends on stomach acid and a protein called intrinsic factor, both of which decline with age, medication and certain gut conditions

Unlike the MTHFD1 encoded enzyme that is a tri-functional enzyme harboring N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase activities, the MTHFD1L encoded enzyme only possesses 10-formyl-THF synthetase activity

AAP use was also linked to a general decrease in gut microbial diversity, especially in women

This makes it a compelling option to consider for effective weight management