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The blood pressure-lowering effect appears to be primarily mediated through weight loss

GLP-1 and Weight Loss: The effects on satiety and caloric intake contribute to GLP-1 agonists' efficacy in weight reduction, supported by numerous clinical trials

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In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]