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However, preclinical studies showed that GIP agonism might activate GABAergic neurons in the brainstem, which in turn will hinder GLP-1-induced malaise, aligning with our results. People using tirzepatide were more likely to experience gastrointestinal events compared with those using SGLT2 inhibitors and insulin
Our results can therefore only reflect upon a potential increase in off-label use and not determine the definitive degree of off-label use
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