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These animals were purchased from the National Veterinary Laboratory (LANAVET) in Garoua (North - Cameroon) and then acclimatised in the animal house of the University of Ngaoundere, Cameroon

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Drug class Thiazide diuretic Mechanism of action Inhibits Na/Cl symporter in the distal convoluted tubule of the kidney Excretion of sodium and water blood volume blood pressure excretion of potassium, magnesium excretion of calcium (can help prevent kidney stones) Clinical uses Hypertension (first-line therapy) Edema (heart failure, nephrotic syndrome, cirrhosis) Prevention of calcium kidney stones Pharmacokinetics Well absorbed orally Renally excreted unchanged Not a prodrug Adverse effects Hypokalemia Hyponatremia Hyperuricemia gout Hyperglycemia (mild) Hypotension Hypercalcemia Contraindications / Caution Severe renal impairment Hypersensitivity to sulfonamides Hydrochlorothiazide = Active drug Chlorthalidone = Active drug Metolazone = Active drug Thiazide diuretics work directly

In his day job, the music BLR produces is definitely not top 40, and he says hes not ready to give up his indie cred. But there are other considerations: Do I really want to be known as the guy who did the song, Everybody Poops?