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GLP-1 RAs in Psoriasis Mechanism of action

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These mechanisms converge to form a multidimensional network that promotes inflammatory imbalance, immune suppression, and metabolic disorders, providing molecular and cellular insights into the association between environmental MP exposure and a range of immune-related diseases

We then built the isobologram of the corresponding dose-response curves with a fixed dose ratio of R and compared the expected mixture of the two doses that produced an effect equal to half of the maximal effect produced by the individual drugs and to the experimental value (see later in methods)