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Wade LA, Katzman R

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We and others have previously identified SW837 rectal cancer and HCT116 colon cancer cells as an in vitro model of inherently radioresistant, and radiosensitive CRC, respectively ( Metformin treatment (2.5 mM and 10 mM) significantly sensitised radiosensitive HCT116 cells to 1.8 Gy radiation, when compared to vehicle control ( Figure 1F ) (relative mean surviving fraction (SF) standard error of mean (SEM)

Taken together, activating GLP-1R not only protected fibroblasts against lactate-induced NLRP3 inflammasome activation, but also inhibited histone lactylation by reducing the expression of p300 thereafter suppressing the transcription of profibrotic genes