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Indications: Terrorism / Chemical Warfare, Weapon of Mass Destruction Effects: Remember muscarinic & nicotinic symptoms SLUDE Symptoms will appear within a few seconds after exposure to the vapor form of sarin and within a few minutes to up to 18 hours after exposure to the liquid form (see below) A long term study of soldiers exposed to sarin & cyclosarin during the first Gulf War (1991) indicated that exposure was significantly associated with less proficient neurobehavioral functioning on tasks involving fine psychomotor dexterity and visuospatial abilities 45 years after exposure (Proctor et al, 2007)

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6 Sirtuins, PARPs & NAD+ (Review)NAD+ as a substrate for sirtuins and PARPs in DNA repair and aging (review)