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Main causes: Ultra-processed food (low in fiber, high in simple sugars) Unbalanced gut microbiota (dysbiosis) Insulin resistance (prediabetes) Lack of sleep (reduces production by 30%) Chronic stress (cortisol inhibits GLP-1) Sedentary lifestyle Good news: Unlike your genetics, your GLP-1 production is completely modifiable by your lifestyle choices
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Evidence supports multiple evidence-informed approaches depending on individual tolerance and biomarker context
In STEP 4 (Rubino et al., JAMA 2021), all patients from week 0 to week 20 reached the full 2.4 mg weekly dose and lost an average of 10.6% of body weight in those 20 weeks
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