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They are involved in multiple biological pathways that could be beneficial in AD including improvement of BBB integrity and vascular health, promotion of homeostasis in microglia and astrocytes, positive effects on adaptative immune cells (including natural killer cells and activated regulatory T cells), improvement of synaptic viability, and neuroprotection [17,18,19,20,21,22,23,24,25,26]

Lilly's triple agonist retatrutide posts its strongest weight loss numbers yet, setting up a 2027 FDA filing Eli Lilly, this week, reported positive topline results from TRIUMPH-2 and TRIUMPH-3, two pivotal Phase 3 trials of retatrutide, a once-weekly injectable that activates receptors for GIP, GLP-1, and glucagon simultaneously a triple mechanism that no approved obesity therapy currently matches