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This constraint has hindered structureactivity relationship studies and rational pharmacologic development

A caveat flagged by the automated peer review: all EC50 values are from heterogeneous published assays using different cell lines and reporter constructs

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Development of AngIV-based analogs Given the above research findings regarding Nle-AngIVs ability to facilitate synaptogenesis and memory consolidation via stimulating the HGF/c-Met system in animal models of AD AngIVbased pharmaceuticals have been proposed as therapeutic agents to treat AD (reviewed in [45,92])