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Since Ozempic is often prescribed for diabetes or prediabetes, adding compounds that influence glucose metabolism requires monitoring

AAV vectors are generally safe at therapeutic doses eight AAV-based gene therapies have been FDA-approved as of 2024 but at high doses, above roughly 10^14 viral genomes per kilogram, the literature documents immune reactions, liver toxicity, and in rare cases, genotoxicity

Indeed, the percentage of dead cells (necrotic+apoptotic cells according to the DNA content analysis) in DEM and BSO treated cells remained low during the first 3 days in culture