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Finally, it can be used to predict patient metabolic and physiological responses to APAP doses and different NAC dosing strategies

C/EBP plays crucial roles in regulating genes implicated in organ development, immune and inflammatory responses, such as IL-6 expression, and macrophage differentiation (Portale et al., 2024)

The transcriptional regulation of DNL is mainly orchestrated by two key transcription factors: sterol regulatory element-binding protein 1c (SREBP1c), which is activated by insulin and liver X receptor , and carbohydrate regulatory element-binding protein (ChREBP), which is activated by carbohydrates [41,42,43] (Fig

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