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Watch for these semaglutide contraindications: A family or personal history of medullary thyroid carcinoma Multiple endocrine neoplasia type 2 Acute pancreatitis Gastroparesis Tell patients to get urgent care if they have bad abdominal pain (it could be pancreatitis, cholecystitis, or a blockage)

When it might shine If your main goal is improving restful, restorative sleep (especially those deep delta-wave sleep periods), maintaining better sleep efficiency, and supporting your sleep-wake cycle without major disruption the nasal spray form of DSIP may be very appealing

Alz Res Therapy 14 , 23 (2022)

05 Persistent injection-site reactions Rotate sites systematically (do not reuse the same square inch within a 7-day window)