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(PubMed) If your goal is body composition optimization (fat loss with strong muscle retention) GLP-1s may still be usefulespecially if appetite dysregulation is part of the picture

33 Interestingly, many clinical studies have demonstrated that the administration of GLP-1 RAs produces a rapid, substantial and dose-dependent reduction in epicardial adipose tissue thickness

This further illustrates the confusion in the literature over the use of the term, PGN vs actual CGN and brings into question the results described by Bash and Vago (1980 Bash, J

Shanzhiside methyl ester (SM), the major iridoid glycoside of Lamiophlomis rotata , demonstrated dose-dependent and long-lasting anti-allodynic effects in neuropathic rats without inducing tolerance [42]