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Dose adjustment recommendations: eGFR 4559 mL/min/1.73 m 2 (CKD stage 3a) : no adjustment for most compounds

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Methods A total of 300 participants, including 114 healthy controls, 92 patients with AHU, and 94 patients with gout, were analyzed by using a combination of dried blood spot (DBS) sampling and mass spectrometry (MS) technology

The STEP 1 trial found that nausea was reported by 44% of participants in the semaglutide group, but the vast majority of nausea episodes were transient and occurred during dose escalation