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However, when combined with potent GLP-1 and GIP receptor activation, those glucose-raising effects are largely balanced while preserving glucagons beneficial effects on energy metabolism

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In addition, a multicenter, randomized controlled trial in patients with T2DM without cardiovascular disease also found that the mean carotid intimal thickness and left carotid intimal thickness after sitagliptin treatment were significantly reduced from baseline, with no significant difference on the right side

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