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Some users report that side effects also follow this pattern, with any nausea or digestive changes most pronounced in the first 24 to 48 hours after injection

40 Preclinical studies have shown that these effects are mainly mediated trough the effects of GLP-1R activation in the central nervous system (CNS) by the modulation of orexigenic and anorexigenic signaling pathways

It would remain to be seen whether, for example, activation of the large population of colonic L cells, for which it is difficult to assign a clear postprandial role, might occur under such conditions

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