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In addition, in October 2024, AstraZeneca announced that it will discontinue marketing brand Byetta

Oral dysbiosis and gut barrier disruption can trigger the same downstream cascade, as pathogenic microbial products traveling from the oral cavity into the digestive tract can further compromise the tight junction environment

This suggests that the GIP component may offer additional metabolic benefits, such as improved fatty acid oxidation, which further protects the kidneys from lipotoxicity

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