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The primary outcome was the change in motor and non-motor symptoms as measured by the Unified Parkinsons Disease Rating Scale (UPDRS) and were interpreted using minimal clinically important difference (MCID) thresholds

[DOI] [Google Scholar] Prez, M

For this reason, health professionals strongly discourage their use

There is little to no evidence to suggest that regular use of B12 supplements or injections has any health benefit, if you do not have a lab-confirmed B12 deficiency