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Importantly, Wegovy is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC), in those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), and during pregnancy or breastfeeding

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387 The SURPASS-5 trial, a 40-week study that enrolled 475 individuals with type 2 diabetes, examined the addition of tirzepatide (5 mg, 10 mg, or 15 mg once weekly) to insulin compared with insulin alone in patients treated with or without metformin

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