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Some evidence suggests that weight loss itself affects thyroid function

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Evidence indicates that skewing may increase with age

Hum Mol Genet 26(2):333343 Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC (2019) Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy