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Conclusion In conclusion, this study establishes a comprehensive forensic biomarker profile for GLP toxicity, characterized by hematological suppression, significant thyroid hormone disruption (elevated TSH, suppressed T3/T4), elevated oxidative stress (increased MDA, decreased SOD), and the induction of apoptotic signaling (downregulated Bcl-2, upregulated Bax and Caspase-3)

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GST non-enzymatic functions GSTs are also implicated as modulators of signal transduction pathways implicated in cell survival and apoptosis, where they control the activity of members of the mitogen-activated protein kinase (MAPK) family 24,25