hypoglycemia with semaglutide following the use of glucagon-like peptide-1 receptor agonists: a real-world analysis of post-marketing surveillance data Semaglutide - wikidoc

The body weight reduction in people with obesity with semaglutide 2.4 mg once weekly is approximately 15%, with simultaneous improvement in cardiometabolic risk factors and physical functioning [10,11]

Muscle loss slows metabolism: without enough protein and resistance training, you may lose lean mass, making regain more likely (see prevention plan below)

But now the brand name manufacturers are pushing the compounding pharmacies to stop

The findings we report here suggest an additional impact of long-term semaglutide treatment in preventing some of the counter-regulatory (adaptive) changes in gut-hormone secretion conducive to weight regain following low-calorie dieting