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GLP1(736) can directly suppress glucagon secretion in cells by increasing cAMP, activating PKA and EPAC, reducing intracellular calcium levels, and thereby decreasing glucagon release

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for example, an analysis of realworld data from the UK showed that liraglutide reduced HbA 1c to a greater extent than lixisenatide (mean treatment difference [95% confidence interval (CI)] 0.3%point [0.56

doi: 10.1002/jps.22592