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Symptoms vary considerably between individuals and may include fatigue, mobility difficulties, visual disturbances, muscle weakness or spasticity, sensory changes (numbness or tingling), cognitive problems, bladder and bowel dysfunction, and pain

The most well-known and biologically active form in humans is alpha-tocopherol

Apart from the fact that the lower legs don't have deep fat compartments, this type of procedure is trickier to perform because the area behind the knee houses blood vessels and nerves that are prone to nerve injury

Reduced anxiety-like behavior and central neurochemical change in germ-free mice