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doi: 10.3389/fcimb.2022.962782 41 ChenX.WuS.ChenC.XieB.FangZ.HuW.et al

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For example, cholesterol oxidation derivatives, such as 7-hydroxycholesterol and 7-ketocholesterol, are significantly elevated in sarcopenia patients and exert cytotoxic effects on myoblasts and myotubes ( 2.4 Factors that aggravate lipid peroxidation Lipid peroxidation drives the pathological progression of sarcopenia through free radical reactions in conditions such as aging, disuse atrophy, denervation, and chronic diseases