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Metformin, widely prescribed for type 2 diabetes, can impair B12 absorption through effects on calcium-dependent ileal uptake
Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]
Unlike GLP-1 agonists, 5-amino-1mq does not work through appetite suppression
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