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Additionally, a high-fat diet induces alterations in gut microbiota, characterized by a decrease in Bacteroidetes and increases in Firmicutes and Verrucomicrobia, the composition of gut microbiota significantly modulates circulating levels of GLP-1, GIP, PYY, and leptin, which potentially impact pancreatic function [6]

Step 2: Reduce (if holding does not resolve it)

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In clinical research, retatrutide has produced weight-loss outcomes that suggest the next generation of metabolic treatment may be even more powerful than what weve seen so far