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It has been shown that the chelating action of BAL is the most efficient in humans and experimental models when administered within a very short time after exposure (Flora et al ., 2008)
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In adipocytes lacking CI, we observed reduced expression of genes involved in the response to insulin stimulus and PI3K/protein kinase B signal transduction (Fig
The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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