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GLP-1 is a naturally occurring hormone in the body, classified as an incretin

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A recent systematic review and meta-analysis observed that adults with obesity or overweight who were administered GLP-1 analogs for at least 12 weeks, showed a significant overall improvement in excess weight loss when compared to a placebo, with a weighted mean difference of 3.11 kg [28]

Glucose consumption, lactate production, insulin secretion and total ATP content assays After pre-conditioning in the presence or absence of 50 nM Exendin-4 for 18 hours, BRIN-BD11 cells or isolated mouse islets were cultured in RPMI containing 20 mM of glucose in the absence of Exendin-4 for additional 24 hours