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Normalizing for time, retatrutide produces approximately 0.5% body weight loss per week at its highest dose, compared to roughly 0.25% for semaglutide and 0.31% for tirzepatide

Consistent with the GLP-1 data, liraglutide treatment increased PC1/3 colocalization with glucagon compared with that in saline-treated controls in WT mice but not in KO mice (Figure 1, D and E

External resources For those seeking the primary scientific literature and authoritative reference materials underlying this comparison, the following resources provide direct access to the most important studies and regulatory information