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Mice were anesthetized using inhaled isoflurane (1-5%, Panion & BF Biotech) in O 2

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However, the decision-making process in primary care is challenging, given the complexity of T2D due to comorbidities, time constraints, guidance overload and the changing scientific landscape of available treatments [3]

15 Both dysbiosis and impaired gut integrity have been strongly associated with the development of overweight, obesity and metabolic syndrome, and should be a key focus of therapeutic protocols either independent of or alongside GLP-1 agonist therapy in supporting weight management