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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)

With the exception of GSH total levels, in which there was a trend to lower levels in serum from patients with ovarian neoplasms compared to healthy individuals, other thiols were mainly in the protein bound form and not free in plasma

Single-cell sequencing and spatial transcriptomics should be used to define cell-type-specific ferroptosis pathways in neurons, astrocytes, and microglia, and determine their functional contributions at key stages of repair

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