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For example, Wegovy (semaglutide 2.4 mg) has a gradual dose escalation over 16-20 weeks, and adverse effects are more common during this escalation period according to product information

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Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance])