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Larger purchase volumes typically come with reduced per-unit pricing, which adds up significantly over the course of multiple orders throughout the year
We appreciate the recommendation to consider an update factor more specific to diagnostic radiopharmaceuticals, which we will consider for future rulemaking
The downsides are cost and convenience
These investigations have examined the compound's biochemical effects in cultured cells and animal models as part of broader research into NNMT and cellular metabolism Importantly, these findings relate to preclinical research and should not be interpreted as evidence of established clinical efficacy, safety or therapeutic benefit in humans
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