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Table of Contents The link between metabolism and neurodegeneration How GLP-1 receptor agonists may affect the brain Current clinical evidence in Parkinsons disease Practical implications for clinicians FAQs Understanding the Metabolic Connection in Parkinsons Disease Parkinsons disease has traditionally been viewed as a movement disorder caused by dopamine neuron loss in the substantia nigra

A brief history of GLP-1RAs GLP-1RAs have an intriguing origin story involving the only venomous lizard in the US, the Gila monster

Yet, whether Rho/ROCK directly mediates TGR5 effects in vivo remains to be confirmed by additional experiments, such as in vivo gene knockout models and Western blot analysis of hypothalamic tissue [68]

Epilepsy Res 142:4552 Wang R, Wang N, Han Y, Xu J, Xu Z (2021) Dulaglutide alleviates LPS-induced injury in cardiomyocytes