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Key cardiovascular and metabolic conditions include: Hypertension particularly nocturnal hypotension or poorly controlled blood pressure Diabetes mellitus both type 1 and type 2, with microvascular complications Hyperlipidemia contributing to atherosclerotic vascular disease Obstructive sleep apnea causing intermittent hypoxia and hemodynamic fluctuations Coronary artery disease reflecting systemic atherosclerosis Smoking promoting endothelial dysfunction and vascular disease Age represents an independent risk factor, with NAION incidence increasing significantly after 50 years

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