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Whereas the levels of 1,2-benzoquinone, 11-dehydro-thromboxane B2, 12-KETE, L-malic acid, N2-succinyl-L-ornithine, ornithine, argininosuccinic acid from the fecal metabolites gradually decreased as CKD progressed, chlorohydroquinone, hydroquinone, L-cystine, fecal 12-keto-tetrahydro-leukotriene B4 (12-keto-tetrahydro-LTB4), and L-cysteine levels gradually increased Integrated network analysis based on metabolomics and metagenomics data revealed that Ruminococcus bromii , fecal hydroquinone, and serum creatinine were the major contributors to this network, therefore play major roles in CKD progression

The GSH/GSSG ratio in the cell has been used as an index of cellular redox status [26,51]

Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity

These two powerhouses create mutually beneficial effects that amplify their individual benefits