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[PubMed] [Google Scholar] 39.Mrakic-Sposta S., Gussoni M., Montorsi M., Porcelli S., Vezzoli A

However, free iron in mitochondria and the cytoplasm can generate highly oxidative HO, which damages polyunsaturated fatty acids (PUFAs) in the phospholipid bilayer, leading to mitochondrial outer membrane permeabilization (MOMP), ultimately abrogating DNA stability and inducing cell death