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Dual-Enzyme (Tandem) Process: Recombinant Kex2 Enzyme + Carboxypeptidase B In contrast, the dual-enzyme (tandem) systemcombining recombinant Kex2 protease and carboxypeptidase B (CPB)offers higher yields and precise cleavage control

Common side effects include nausea, diarrhea, vomiting, constipation, indigestion and stomach pain

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Furthermore, it has been shown that physiological high estradiol levels correlate with increased leptin sensitivity and that reduced leptin sensitivity after oophorectomy can be restored with estrogen treatment (154)