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Because many mitochondrial metabolites are cofactors for epigenetic regulators, mitochondrial stress is thought to drive aging-associated epigenetic drift in stem cells 41,56

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These studies can also help to establish health care resource utilisation benefits, and provide cost implications for the use of SGLT2 inhibitor and GLP-1 RA therapies in everyday practice [132]

An unexpected finding in our studies was the loss of improved lipid tolerance in Dpp4 EC/ mice, with or without coadministration of sitagliptin, following BMT, implying an interaction between bone marrowderived cells and the metabolic actions emanating from the reduction of DPP-4 activity in endothelial cells