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2017;7(5):e1119

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To further examine the possibility that MK-801 could convey protraction, we synthesized a series of conjugates comprising MK-801 in combination with other peptide analogues, peptide YY (PYY), glucose insulinotropic peptide (GIP) as well as a GIP/GLP-1 co-agonist, for which half-life extension has been shown to enhance weight loss efficacy 23,24,25,26

Strikingly, a high number of proteins more than 80% from all models exhibited differential mean expression between control and cKOt mice (Figure 1J), demonstrating the substantial effect of Bmal1 deletion on the renal proteome