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Most published studies are small, involve patients affected by obesity and/or T2DM, and may therefore not be fully generalizable to the broader PsO/PsA population

Unlike GSH, for which only the reduced form is an antioxidant, both the oxidized and reduced forms of LA are powerful antioxidants whose functions include: (1) quenching of reactive oxygen species (ROS), (2) regeneration of exogenous and endogenous antioxidants such as vitamins C and E, and GSH, (3) chelation of metal ions, and (4) reparation of oxidized proteins (5) regulation of gene transcription (6) inhibition of the activation of nuclear factor kapp B (NF-B

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For instance, pharmacological enhancement of mitophagy via urolithin A or NAD + precursors has been shown to rescue cognitive function in diabetic mice, underscoring the therapeutic potential of targeting autophagic pathways in metabolic cognitive disorders