glp-1 agonist dpp 4 inhibitor Dipeptidyl peptidase inhibitors in the treatment of type 2 diabetes mellitus Effects of GLP-1 and DPP-4

M., Muhlhausen, C., Haege, G., Hoffmann, G

In some embodiments, the formulation or composition has a viscosity of at least about 10 cP, about 20 cP, about 30 cP, about 40 cP, about 50 cP, about 60 cP, about 70 cP, about 80 cP, about 90 cP, about 100 cP, about 200 cP, about 300 cP, about 400 cP, about 500 cP, about 600 cP, about 700 cP, about 800 cP, about 900 cP, about 1,000 cP, about 2,000 cP, about 3,000 cP, about 4,000 cP, about 5,000 cP, about 6,000 cP, about 7,000 cP, about 8,000 cP, about 9,000 cP, about 10,000 cP, about 15,000 cP, or about 20,000 cP

GST catalyzes the conjugation of reactive metabolites, such as phosphoramide mustard, into less toxic compounds like 4-glutathionyl-cyclophosphamide (Dirven et al., 1994)

Cleveland Clinic Journal of Medicine, 90 (9), 545-548