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Panel B shows the GSH regulatory motif (taken from Figure 1), including the effects of estradiol and the inhibition of GCL and glutathione synthetase (GS) by GSH

In addition, lovastatin transcriptionally suppresses programmed cell death 1 ligand 1 (PD-L1) expression and induces ferroptosis, further underscoring its therapeutic potential in NSCLC ( Another statin, simvastatin (in micromolar doses) also suppresses PD-L1 expression and enhances antitumor immunity in colorectal cancer by down-regulating long non-coding RNA (lncRNA) small nucleolar RNA host gene 29 (SNHG29)

earlier studies with the double glycosylation of cysteine-containing peptides via installation of an alkyne at the Cys thiol using propargyl bromide, followed by sequential thiol-yne-thiol-ene couplings (Conte et al., Figure 6A) (Fiore et al., N and C terminus